The Extent of Consequential DNA Damage in Human Tumors from TCGA PanCanAtlas

DNA damage is crucial for the emergence of cancer cells. If response defective, converted to fixed mutations. Some these mutations drive tumorigenesis and are called driver However, extent consequential per tumor, i.e., number various kinds mutations, not known. We utilized largest database human (TCGA PanCanAtlas), multiple popular algorithms prediction, several custom scripts estimate in primary tumors. found that there were on average 22 patient’s which 1.7 point oncogenes, 8.5 amplifications 1.6 tumor suppressors, 3.9 deletions 1.5 chromosome losses, 1 was gain, 2 arm gains. The increased with age, from 11.2 25 y.o. 28.6 >85 varied strongly between types, 1.9 thyroid carcinoma 49 lung squamous cell carcinoma. Overall, our results provide valuable insights into functional